CLINICAL FEATURES OF BOOP
–
Occurs in adults of all ages, not related to smoking
– Usually a subacute illness: 1/3 present with flu-like illness,
1/3 with cough, 1/3 with cough and dyspnea
– On examination: Fine end inspiratory crackles in 2/3. No clubbing.
– Laboratory features: increased ESR. Low PaO2 " CXR: 4 patterns
evident: (1) bilateral patchy infiltrates- airspace or mixed pattern (2)
bilateral linear and nodular opacities (3) focal consolidation (4) multiple
large nodules or masses
– HRCT: areas of air space consolidation, small nodules or both.
Sometimes ground glass opacities.
– PFT's: restrictive pattern with low DLCO. No obstruction
as you would see in pure bronchiolitis obliterans.
– BAL cytology: increased lymphocytes +/- eosinophils
– Steroid Response: about 80% have complete resolution within 6 months
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