Simon Couillard, MD, MSc
Université de Sherbrooke, Sherbrooke, QC

Fractional exhaled nitric oxide (FeNO) is a biomarker of type-2 inflammation associated with interleukin (IL-13) activity. It is also highly corticosteroid responsive – the basis for the FeNO suppression test to identify people with nonadherence. In this framework, people who suppress FeNO significantly during monitored high-dose inhaled corticosteroids (ICS) are labelled as nonadherent/corticosteroid sensitive. But what about the ‘nonsuppressors’, i.e. those who fail to suppress FeNO?

In this presentation, Dr. Couillard will review the mechanisms for FeNO elevation and suppression, then present data emerging from his time at the University of Oxford showing how FeNO non-suppression is mechanistically and clinically relevant to medical practice.

Learning Objectives:
At the end of this presentation, attendees will be able to:

  • Explain the mechanisms of FeNO elevation and suppression; and
  • Understand the mechanistic and clinical significance of FeNO non-suppression.