Parameswaran Nair, MD, PhD, FRCP, FRCPC, FCAHS
McMaster University; Hamilton, ON

Session Description

This lecture will examine the definition and identification of “T2 low” asthma, clinical presentations and physiological associates of this “endotype”, and potential pharmacological and non-pharmacological interventions for asthma control. The lecture will pay particular attention to neutrophilic inflammation of the airways, the role of infections and hyperresponsiveness, and data from clinical trials targeting non-T2 pathways in asthma.

Learning Objectives

At the end of this presentation, attendees will be able to:

  • Understand Endotype severe asthma in clinical practice
  • Understand mechanisms of T2 low asthma, emphasis on infections and role of mast cell
  • Apply practical approach and management to apparent T2 low asthma

CanMEDS Roles: Communicator, Health Advocate, Medical Expert, Scholar