Dr. Gregory Downey, National Jewish Health, Denver, CO, USA

This presentation will begin with a series of clinical cases that represent actual clinical scenarios of patients who have presented for evaluation of diffuse cystic lung disease. It will include high-resolution chest CT images and a discussion of the differential diagnosis. A more detailed mechanistic discussion of selected diffuse cystic lung diseases will be provided including lymphangioleiomyomatosis (LAM), Birt Hogg Dubé Syndrome, lymphocytic interstitial pneumonitis (LIP), and Langerhans’ cell histiocytosis (LCH). A discussion of the genetic basis of specific diffuse cystic lung diseases and current treatment recommendations, where available, will be provided. Finally, a diagnostic algorithm that represents a logical approach to the differential diagnosis of diffuse cystic lung disease will be discussed.

Learning Objectives
At the end of this presentation, attendees will be able to:

  • Review the diverse clinical presentations of patients with cystic lung disease;
  • Learn about the latest information on the genetic basis of cystic lung disease and the use of molecular diagnostic testing; and
  • Learn about an algorithmic clinical, radiological, and genetic analysis approach to patients with cystic lung disease.

CanMEDs Competencies addressed:
Collaborator, Communicator, Health Advocate, Leader, Medical Expert, Professional, Scholar