Dr. James C. Hogg, UBC Heart Lung Innovation, Vancouver, BC
Earlier study by our group showed that the terminal bronchioles are reduced by approximately 90% in very severe (GOLD 4) COPD. In addition a subsequent study confirmed and substantially extended the observations in the initial report by showing patients with mild (GOLD 1) and moderate (GOLD 2) COPD have already lost approximately 30-40% of their terminal bronchioles. The purpose of this presentation is to show new experimental evidence that the reduction in terminal bronchiolar number in lungs affected by COPD takes place in regions of microscopic emphysematous destruction confirmed and extended using a combination of microCT, quantitative histology , and gene expression profiling.
At the end of this presentation, attendees will be able to:
- Identify the site of small airway obstruction in COPD;
- Improve their understanding of the pathology of small airway obstruction; and
- Appreciate why small airway disease can accumulate without being noticed by either the patient or the physician responsible for their care.