Glenda Bendiak, MD, MSc, FRCPC
Alberta Children’s Hospital and University of Calgary, Calgary, AB

This session will review selected pulmonary complications of sickle cell disease and the role of the respirologist in their management. The management of acute chest syndrome will be discussed, including novel diagnostic strategies and the potential role for early non-invasive ventilation. The associations between wheezing, asthma, airway hyper-responsiveness, and atopy in patients with sickle cell disease will be explored to highlight the challenges in diagnosing and managing asthma in this patient population. Finally, emerging disease-modifying approaches for children with sickle cell disease will be reviewed, with a particular focus on recent literature describing their impacts on pulmonary outcomes of interest.

Learning Objectives
At the end of this presentation, attendees will be able to:

  • Describe the clinical entity of acute chest syndrome, including emerging management strategies for this condition;
  • Define the challenges of diagnosing and managing asthma in this patient population; and
  • Discuss the pulmonary function abnormalities common in patients with sickle cell anemia and novel therapies which may alter their trajectory.

CanMEDS Roles Addressed: Health Advocate, Leader, Medical Expert, Scholar