Dr. Malcolm Sears, McMaster University, Hamilton, ON
Dr. Padmaja Subbarao, Hospital for Sick Children, Toronto, ON

The Canadian Healthy Infant Longitudinal Development (CHILD) study, a national birth cohort study of almost 3500 infants, their mothers and most fathers, is one of the largest intensively investigated and phenotyped population-based cohorts focused on understanding the diversity of environmental and host factors predisposing to asthma and allergy. Funded by CIHR and the Allergy, Genes and Environment (AllerGen) NCE, and sustained by AllerGen, this landmark Canadian study involving some 50 investigators and their teams has produced key insights into environmental, genetic, nutritional and microbiome factors associated with these conditions. All 5-year-old assessments have been completed, with over 90% retention, and assessments of the cohort at 8-9 years are underway. We will identify new knowledge gained from this study relating to Developmental Origins of Health and Disease (DOHaD) and highlight the ongoing importance of this study to Canadian research in non-communicable diseases, particularly respiratory and allergy-related, and the public.

Learning Objectives
At the end of this presentation, attendees will be able to:

  • review the gaps in knowledge about the development of asthma and allergy and why the CHILD Study was initiated;
  • provide novel insights into the development of asthma and allergy from infancy gained from the CHILD study; and
  • indicate the potential for continuation of CHILD including multidisciplinary studies of the Developmental Origins of Health and Disease.